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Furthermore, GLP-1 secretion is defective in obesity, leading to high caloric intake and subsequent weight gain

Trimethylamine N-oxide promotes atherosclerosis by regulating low-density lipoprotein-induced autophagy in vascular smooth muscle cells through PI3K/AKT/mTOR pathway

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For drugs with robust patent estates extending beyond year 13, the IRA clock becomes the effective LOE for pricing purposes regardless of remaining patent term, making those late-stage patents commercially worthless even if legally valid

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