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doi: 10.1155/2016/4579149 46 HanawaN.ShinoharaM.SaberiB.GaardeW

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To test if any cystinosin mutants could be constitutively degraded, we generated a plasmid library by fusing 37 disease-causing CTNS mutations with a c-terminal GFP tag

While co-expression of BTRs with CCK-secreting I-cells has not been assessed in humans, oral administration of encapsulated HCl quinine (18 mg) was recently reported to increase plasma CCK concentrations and reduce energy intake at an ad libitum meal in healthy young individuals (62)

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