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Arthritis & Rheumatology by Joseph F Merola and colleagues evaluated whether combining ixekizumab (IXE), an IL-17 inhibitor, with tirzepatide (TZP), a GLP-1 receptor agonist, could offer enhanced clinical benefits compared to ixekizumab alone in adults with active PsA and excess weight

Reagents GLP-1(736), GLP-1(936), exendin-4 and exendin(939) were from Bachem (Weil am Rhein, Germany), the glucagon receptor (GCGR) antagonist REMD2.59 was from REMD Bioptherapeutics (Camarillo, CA, USA) and pertussis toxin (PTX) was from Sigma (Gillingham, Dorset, UK)

Patients should tell their doctor if each dose increase brings stronger nausea, fatigue, reflux, constipation, or inability to eat

J Dermatolog Treat 33(3):14281434 Faurschou A et al (2015) Lack of effect of the glucagon-like peptide-1 receptor agonist liraglutide on psoriasis in glucose-tolerant patientsa randomized placebo-controlled trial

Unlike traditional antidiabetic drugs, GLP-1 analogs leverage the peptide's ability to stimulate insulin release while minimizing hypoglycemia risk

Does GLP-1 therapy replace diet and exercise