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Zinc status and polycystic ovarian syndrome: A systematic review and meta-analysis

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The results will be presented as a narrative synthesis according to the Synthesis Without Meta-analysis (SWiM) Reporting Guideline

In estrogen biology, GSTM1 and GSTT1 serve a specific and critical function: they conjugate the reactive quinone metabolites produced when catechol estrogens particularly 4-OHE2 (4-hydroxyestradiol) are not rapidly methylated by COMT or sulfated by SULT1A1 and instead undergo further oxidation: The oxidation cascade: CYP1B1 converts estradiol to 4-OHE2 if COMT and SULT1A1 cannot clear 4-OHE2 quickly, one-electron oxidation produces 4-OHE2 semiquinone two-electron oxidation produces 4-OHE2 quinone (4-OHE2-Q)

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10.1038/nrd2804