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Salivary acetylcholinesterase activity is increased in Parkinsons disease: a potential marker of parasympathetic dysfunction

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People were tested on these weekly doses: 1 milligram (mg) 4 mg (starting at either 2 mg or 4 mg) 8 mg (starting at either 2 mg or 4 mg) 12 mg (starting at 2 mg) The highest dose tested was 12 mg per week , and the gradual increase was important for making side effects easier to handle