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Chen Z, Hong Q

The full glycemic effect typically develops over several weeks as the medication reaches steady-state concentrations in the bloodstream

[DOI] [PubMed] [Google Scholar] 111.Hopkins ND, Cuthbertson DJ, Kemp GJ, Pugh C, Green DJ, Cable NT, et al

COPD patients experience a progressive limitation of airflow, arising from two primary pathological processes: remodeling and narrowing of the small airways, and destruction of the lung parenchyma, which results in the loss of alveolar attachments due to emphysema [133]

But 10% had more severe side effects, and 7% stopped using it because of the discomfort

doi: 10.1038/s41574-019-0156-z 165 HeLHYaoDHWangLYZhangLBaiXL