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Grading of the results The SoF table presents the grades for the certainty of the evidence supporting the primary outcome of the meta-analysis (Supplemental Table S2)

However, when circadian rhythms are disrupted and the SCN becomes dysregulated, these effects can compound, leading to impaired detoxification, upregulated inflammatory cytokines, and increased hepatic lipid accumulation

and inflammation both results from and contributes to dysbiosis and altered GLP-1 levels

Clinicians may consider pancreatitis, gallbladder disease, bowel problems, or dehydration-related complications depending on the full picture

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IGF1R signalling and its inhibition