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Dosage / Administration of B12 Injections Subcutaneous shots can be administered instead of intramuscular - means injecting with a very short needle into the fat layers around your abdomen or thighs - easier for self-administration and the B12 is released slowly

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Long-term use of certain medications such as metformin and proton pump inhibitors (PPIs) also increases the risk of B12 deficiency

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Constipation is managed with adequate fiber, hydration, and if needed, gentle fiber supplements

In the scenario of cobalamin deficiency, the methylation of Hcy to methionine will essentially lead to an excessive turnover of Choline resulting in a posited cholinergic deficiency