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Technol Cancer Res Treat 21:153303382210809

Importantly, covalent and noncovalently bound ligands may coexist in the crystal structure, as was demonstrated for reversible covalent cyanoacrylamide inhibitors targeting non-conserved cysteine Cys909 in an induced fit binding pocket of Janus kinase JAK3 (Figure 6D) (PDB: 5LWN) [122]