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Compared to unaltered chitosan, quaternization dramatically improves bioavailability across a much broader pH and variation in concentration by maintaining the positive charge of the chitosan at neutral pH

Biol Cell

found that DA neurons in the midbrain of rodents that project to the dorsal parts of the nucleus accumbens (near the border of caudate) signal learning from lack of expected rewards 9

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The results of this study can help to inform strategies to increase utilization of novel medications when appropriate, and to target efforts to ensure patients are receiving medications that have real benefits for them, especially high-risk, vulnerable populations who, owing to inherent biases in medical practice, can be excluded from these therapies, the researchers wrote