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World Obesity calls for: Inclusion of GLP-1 therapies in national essential medicines lists and universal health coverage (UHC) benefit packages Public-sector availability of treatment, not just access via private markets Targeted investment to avoid widening health inequities, particularly for disadvantaged communities Affordable pricing strategies and innovation from manufacturers to expand global access Bridging critical gaps in evidence The introduction of GLP-1 therapies into global health systems must be accompanied by continued research, particularly in areas where evidence is currently thin

There is little doubt these drugs have transformed obesity medicine

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Horm Metab Res 36(1112):804810 Puchalska P, Crawford PA (2017) Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics

Sublingual placement ensures 7080% bioavailability, whereas swallowing reduces it to approximately 510%