ML365 Size:Solid 2 mg InChi: InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-64-35)37-10-8-36(9-11-37)32-63-53(70)45-29-41(68)33-66(45)54(71)52(57(2
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ML365 Size:Solid 2 mg InChi: InChI=1S/C58H65F2N7O11S/c1-35-51(79-34-64-35)37-10-8-36(9-11-37)32-63-53(70)45-29-41(68)33-66(45)54(71)52(57(2ML365 is a potent and selective K2P3. 1 TASK 1 channel blocker. ML365 blocks TASK1 channels in both the thallium influx fluorescent assay (IC50 = 4 nM) and an automated electrophysiology assay (IC50 = 16 nM). Based on potency differences, it possesses more than 60 fold selectivity for inhibition of TASK1 over a closely related, two pore domain potassium channel, TASK3. ML365 displays little or no inhibition at 30 M of more distantly related potassium
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