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The clinical study protocol and the statistical analysis plan are provided in the Supplementary Information as Supplementary Notes 2 and 3, respectively, and are referenced in this Data Availability Statement

The first strategy is by inhibiting the activity of the dipeptidyl peptidase-4 by DPP-4 inhibitors

Concomitant metformin use was therefore not associated with an increased risk of serious GI adverse events, nausea, vomiting, or discontinuation of the study product throughout the trial in SUSTAIN ( The results of our study are subject to several limitations

Not applicable

Some of the conditions that may benefit from LDN therapy include: Autoimmune & Inflammatory Conditions : Rheumatoid Arthritis, Lupus, Multiple Sclerosis (MS), Hashimotos Disease, Inflammatory Bowel Disease, Crohns Disease, Psoriasis Chronic Pain & Neurological Disorders : Fibromyalgia, Chronic Fatigue Syndrome (CFS), Complex Regional Pain Syndrome (CRPS), Migraine Headaches Gastrointestinal Disorders : Irritable Bowel Syndrome (IBS), Periodontal Disease Endocrine & Metabolic Conditions : Addisons Disease, Hypothyroidism, Polycystic Ovary Syndrome (PCOS) Mental Health & Neurological Disorders : Anxiety, Obsessive Compulsive Disorder (OCD) Skin Conditions : Eczema, Atopic Dermatitis, Alopecia Areata How Does LDN Work

BMC Vet Res (2012) 8:112