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Reducing the use of D2 antagonists can prevent these effects, as use of clozapine, a nonprolactin-raising antipsychotic that does not have high affinity for D2 dopamine receptors, increased bone mineral density in schizophrenic patients (Lin et al., 2019) and reduced development of osteoporosis when used alongside prolactin-raising antipsychotics in schizophrenics (Qiu et al., 2020)

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Moreover, alcoholics may experience reduced intestinal absorption of vitamin B 12 (2), and individuals with acquired immunodeficiency syndrome (AIDS) appear to be at increased risk of deficiency, possibly related to a failure of the IF-B 12 receptor to take up the IF-B 12 complex (3)