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Nature 430 , 917921

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The combination group showed significantly higher improvement scores than the dermaroller-only group at baseline and Week 3, with p-values indicating statistically significant differences

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This likely makes them less useful for some users, but it can also reduce the chances of experiencing side effects

For example, the lactylation of K230 and K322 on ALDOA abolishes its interaction with dead-box deconjugate enzyme 17 (DDX17), thereby enhancing the regulatory function of DDX17