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Figure 1 Ionotropic Receptors These receptors are all cation-permeable, homo- and heteromeric blocks of structurally distinct subunits ( In several animal models, NMDA-R antagonists have been shown to produce antidepressant-like effects ( Historically, NMDARs have received more attention as they are key players in the process of excitotoxicity, a pivotal mechanism in stroke and neurodegenerative disorders

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Int J Mol Sci 14:38343859 Sami DH, Soliman AS, Khowailed AA, Hassanein EH, Kamel EM, Mahmoud AM (2022) 7-hydroxycoumarin modulates Nrf2/HO-1 and microRNA-34a/SIRT1 signaling and prevents cisplatin-induced oxidative stress, inflammation, and kidney injury in rats

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These exclusions were applied to maintain data reliability, although the potential for language and publication bias is acknowledged