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Monotherapy with the once weekly GLP-1 receptor agonist dulaglutide for 12 weeks in Japanese patients with type 2 diabetes: dose-dependent effects on glycaemic control in a randomised, double-blind, placebo-controlled study

Results: A total of 6,225 patients (mean age 61.9 years, 36.5% females) with available primary outcome data were included in these analyses

Of an administered dose, about 53% is excreted in the urine and 38% in faeces, both as unchanged drug and metabolites (Wang et al., 2015)

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84 Nevertheless, the results from the studies are conflicting, and sufficiently large genomic studies are needed to further develop the understanding