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Serious Side Effects Seek immediate medical care if you develop the following signs and symptoms: Seizures Fever Muscle pain or joint pain Confusion Paranoia (irrational fears) Hallucinations (seeing or hearing things that arent there) Mania (abnormal excitement) in people with undiagnosed bipolar disorder Skin rash, hives, itching, peeling, blisters (signs of an allergic reaction) Swelling of the face, eyes, lips, tongue, throat, hands, feet, or lower legs Fast, pounding, or rapid heartbeat Trouble breathing or swallowing Allergic reactions Worsening depression or suicidal thoughts Factors Affecting Wellbutrin Dosage Decisions Kidney and Liver Function Mild to moderate liver impairment: Use with caution