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Adjuvants are generally considered safe

placebo at 6 months] 1.3, 95%CI 0.891.88) in 300 people with HF, with and without type 2 diabetes and with recent decompensation (Margulies et al., 2016)

Clinical trials show weight loss continues progressively over 12 to 18 months before reaching a plateau at the maintenance dose

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In the Phase 2 dose-finding trial, men and women receiving cagrilintide 4.5 mg achieved mean weight loss of 10.8% over 26 weeks