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Timothy Piatkowski, Senior Research Fellow in Public Health, The University of Queensland

20 , 21 Much earlier, Selyes concept was born outside of the gastrointestinal tract, in the adrenal gland, and Selye conceptualized the general syndrome of adaptation (i.e., adrenal gland hypertrophy, thymolymphatic involution, and stomach stress ulcers) to achieve general homeostasis in the whole body while the derangement could explain the genesis of many stress-induced diseases

While a B12 supplement may not cause harm, Dietary Guidelines for Americans, a government publication that provides nutrition advice to the public, recommends getting most nutrients primarily from food and beverages