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Providers commonly explain that pushing toward a high number without confirmed tolerance at earlier stages tends to increase the likelihood of side effects rather than improve results

In AD, glutamatergic and cholinergic synapses of the temporal lobe are affected first, followed by a spread to other regions (Golde, 2006)

In an in-vivo study, it has been seen that mitochondrial ROS can have less detrimental effects in worms by increasing their lifespan while increased level of ROS in cytoplasmic may have less lifespan of worms [43]