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This has the advantage of showing the outcomes associated with MBS and GLP-1 RAs in routine clinical application and reflecting clinical practices in obesity management more closely than randomized trials, but it also has the potential disadvantage of introducing biases and confounding factors

The efficacy of a subcutaneous injection of soluble Vitamin B12 in lambs

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FDA-approved candidates include adults with BMI 30 kg/m or BMI 27 kg/m with weight-related comorbidities such as hypertension, dyslipidemia, or cardiovascular disease

Quality of evidence assessment The evidence quality of the outcomes of interest was assessed systematically based on the GRADE framework that takes into consideration the risk of bias, inconsistency, indirectness, imprecision, and magnitude of effect