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Abbreviations AA Ascorbic acid AJs Adherens junctions Alb Albumin AMPA receptor -Amino-3-hydroxy-5-methyl-4-isoazole receptor AP-1 Activator protein-1 AQP4 Water channel protein-4 ASMs Antiseizure medications Bax Bcl2-associated X BBB Blood-brain barrier Bcl-2 B-cell lymphoma-2 BDNF Brain-derived neurotrophic factor CAT Catalase CBP Calcium-binding proteins cGMP Cyclic guanosine monophosphate CNTF Ciliary neurotrophic factor COX Cyclooxygenase DRE Drug-resistant epilepsy ECs Endothelial cells FMT Fecal microbiota transplantation GABA -Aminobutyric acid GAD1 Glutamic acid decarboxylase GAT GABA transporter GCLC Glutamate cysteine ligase GDNF Glial cell-derived neurotrophic factor GFAP Glial fiber acidic protein GGT -Glutamyl transpeptidase Gln Glutamine Glu Glutamate GPx Glutathioneperoxidase GR Glutathione reductase GS Glutamine synthetase GSH Glutathione HDL High-density lipoprotein HO-1 Heme oxygenase-1 IFN- Interferon- IKK IB kinase IL Interleukin iNOS Inducible nitric oxide synthase Kir 4.1 Inwardly rectifying potassium channel 4.1 LOX-15 Lipoxygenase 15 LPS Lipopolysaccharides L-VSCC L-type voltage-sensitive Ca 2+ channel MAPK Mitogen-activated protein kinase MDA Malondialdehyde MFS Moss fiber germination MMP Matrix metalloproteinase mPTP Mitochondrial permeability transition pore MyD88 Myeloid differentiation primary response gene 88 MADPH Nicotinamide adenine dinucleotide phosphate NADPH-OX Nicotinamide adenine dinucleotide phosphoribonucleotide oxidase NF-B Nuclear factor kappa-B NGF Nerve growth factor NLR Nucleotide-binding oligomerization domain-like receptors NMDA receptor N-methyl-D-aspartate receptor NO Nitric oxide NSCs Neural stem cells nNOS Neuronal-type nitric oxide synthase NOS Nitric oxide synthase NR2 A/B NMDA receptor subunits 2A and 2B NSCs Neural stem cells NT Neurotrophin OL Oligodendrocyte OPN Osteopontin OS Oxidative stress PARP-1 Poly ADP-ribose polymerase-1 P-gp P glycoprotein PLP Pyridoxal phosphate PKC Protein kinase C PRRs Pattern recognition receptors RAR Retinoic acid receptor RIP-1 Receptor-interacting protein 1 RIPK2 Receptor-interacting serine/threonine-protein kinase 2 RNS Reactive nitrogen species ROS Reactive oxygen species SCFAs Short-chain fatty acids SIRT1 Silent mating type information regulation 2 homolog-1 SOD Superoxide dismutase TAB TAK-binding proteins TAK1 Transforming growth factor--activated kinase 1 THEM4 Thioredoxin superfamily member 4 TIRAP Toll interleukin 1 receptor domain containing adapter protein TJs Tight junctions TLE Temporal lobe epilepsy TLR Toll-like receptor TNF- Tumor necrosis factor- TRAF6 Tumor necrosis factor receptor-associated factor 6 VD Vitamin D VDH Vitamin D hormone VDR Vitamin D receptor VDREs Vitamin D response elements ZO Zonula occludens Authors contributions All authors participated in the writing of this manuscript

Nausea, vomiting, and constipation are the most frequently reported side effects, particularly during the first 24 weeks and when doses increase

Inflammation Modulation Down-regulation of pro-inflammatory cytokines

However, endogenous production may decline with age

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