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Gender-based considerations The phase 2 trial included both men and women, and the results did not show statistically significant differences in weight loss between genders at matched doses

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Indeed, mutations at these highly conserved residues lead to MC1R inactivation, and are found in red-headed individuals (Figures 6)

While this study must be regarded as preliminary because inflammatory markers were found to be an unsuitable primary endpoint in our setting, the CARPAN trial provides the basis for a robust sample size calculation: a conclusive study of L-Carnitine benefits ought to enrol 148 patients in each arm to show a survival benefit with 90% power, and would need 157 patients in each arm to demonstrate an improvement in tumor fatigue

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