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By the end of the 1960s it was clear that there were a number of peptide substances with similar biological properties to glucagon present along the entire length of the intestine, from the duodenum to the rectum

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"Both semaglutide and tirzepatide are well-known for their effects on weight loss and blood sugar control, but our study suggests they may also offer substantial benefits to patients with obesity and type 2 diabetes by reducing adverse heart failure outcomes." Despite promising results from existing randomized controlled trials of semaglutide and tirzepatide in those with obesity-related HFpEF, regulatory authorities and professional societies have not approved or endorsed the use of these drugs for HFpEF, due in part to the studies relatively small sample sizes and unknown generalizability

GLP-1 medications should not be taken if you are pregnant or breastfeeding

Intern Emerg Med [Internet]

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