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Glucagon-like peptide-1 (GLP-1) receptor agonists, medications FDA-approved for type 2 diabetes and chronic weight management, are generating scientific interest for potential effects on substance use disorder

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The 60/40 approach places 60 percent of the dose in the morning (fasted) and 40 percent in the evening (before dinner or before bed)

Splitting the dose across two weeks would create unpredictable hormone fluctuations, potentially leading to inconsistent appetite suppression, metabolic dysregulation, or unnecessary side effects

they are chemically distinct molecules

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