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Mishra RK, Ahmad S, Verma A, Mishra H

It is also a substrate for enzymes like sirtuins and poly(ADP-ribose) polymerases (PARPs), which regulate gene expression, DNA repair, and cellular stress responses

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In gastric cancer, SAMe is able to reverse the hypomethylated status of genes such as uPA , c-myc and H-ras inhibiting tumor growth, both in vitro and in vivo [198,261]

Band intensity (revealed as optical density-OD) were detected by ImageJ software

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