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The effect of O-6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)-1-nitrosourea, and cisplatin

These observations indicate that CBS is insignificant in GSH synthesis through the TSS pathway under current experimental conditions

6 Mild elevations in liver enzymes less than twice the upper limit of normal occur in 15% to 25% of patients

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In reality due to the kinetics of HDIVC and IV GSH there is some question regarding the time required between IV GSH and high dose IVC (or most oxidative therapies**)