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Similarly, interferon regulatory factor 1 upregulation by IFN reduces SLC7A11 transcription through Janus kinase (JAK) (82)

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The reaction can be generalised as such: 1 -amino acid + R 2 --ketoacid R 1 --ketoacid + R 2 -amino acid A very common -keto acid is -ketoglutarate, an intermediate in the citric acid cycle