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How Tirzepatide Works Tirzepatide is a unique medication that mimics the effects of two naturally occurring incretin hormones in the body: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)

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Hackensack University Medical Center physician perspective on the SELECT trial The SELECT trial, published in The New England Journal of Medicine on November 11, reported that the GLP-1 receptor agonist semaglutide reduces risk of cardiovascular events in patients with obesitybut thats not the question we ought to be asking, suggests Nathaniel Lebowitz, M.D., cardiologist, Hackensack University Medical Center, and assistant clinical professor of Cardiology at Hackensack Meridian School of Medicine