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It is important to mention here that polyphenols cannot cross the blood-brain barrier and may have low bioavailability in the brain, but the intestinal lumen contains them in abundance, and hence, have the ability to modulate the microbiota, which is of utmost importance in the pathogenesis of ASD [197]

It suggests either multiple pathways activated at different dose ranges or extreme potency with receptor saturation at low doses

The math is not complicated once you understand the relationships, but a single miscalculation can lead to dramatically wrong doses

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Injectable routes (subcutaneous or intramuscular) are common for musculoskeletal injuries and may provide more predictable dosing

At these tiny doses, precision is everything