Phospho-Akt (S473) Polyclonal Antibody, 20ul[BT-PHS00864] Microplate Mixer Diseases associated with TRAK2 include

Diseases associated with TRAK2 include amyotrophic lateral sclerosis 2

The protein associates with the U3 small nucleolar ribonucleoprotein 60-80S complexes and may be involved in pre-rRNA processing

and dilution

Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis

The protein (minichromosome maintenance complex component 2) encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication

Phospho-Akt (S473) Polyclonal Antibody, 20ul[BT-PHS00864] Microplate Mixer Diseases associated with TRAK2 includeThe serine threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3 kinase. In the developing nervous system AKT is a