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BPC-157 has been observed to downregulate pro-inflammatory cytokines and protect against NSAID-induced tissue damage, while TB-500 may modulate macrophage activity and support immune cell migration

TB-500 is classified under WADA category S2 as a peptide hormone, growth factor, related substance and mimetic also banned in and out of competition

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Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression

For instance, patients with Wolfram Syndrome (WS) have rare autosomal recessive mutations in their WFS1 gene that give rise to multiple complications, such as juvenile-onset diabetes, optic atrophy, and deafness (185)

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