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4.5 Metabolic reprogramming and adipocyte crosstalk Metabolic reprogramming is one of the hallmarks of the breast cancer progression and is strongly influenced by the complex interactions among tumor cells and nearby adipocytes present within the TME (122, 123)

James Grant, the plan medical director, was among the most direct in explaining the rationale, pointing to the combination of skyrocketing costs and poor adherence as the primary drivers

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