Rb Polyclonal Antibody, 20ul[BT-AP07693] Pathway and Network Analysis There are two isoforms of

There are two isoforms of PRPF38A that are produced as a result of alternative splicing events

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Mutations have been associated with X-linked dyskeratosis congenita

In several BTB/POZ containing proteins

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Rb Polyclonal Antibody, 20ul[BT-AP07693] Pathway and Network Analysis There are two isoforms ofThe protein encoded by RB1 (RB transcriptional corepressor 1) is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in RB1 are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.