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Thus, in analogy to the anti-ferroptotic function of DHODH 19 , we proposed the following working model: LDHB reduces ubiquinone to ubiquinol in the inner mitochondrial membrane, thereby suppressing mitochondria-associated ferroptosis (Fig
Additionally, the eyes are almost on top of the head, which allows a frog to hide nearly submerged in water with only its eyeballs and nostrils exposed (below right)
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These include diarrhea, nausea, stomach pain, vomiting, and constipation
Access this article Similar content being viewed by others Abbreviations AA: Ascorbic acid Asc.-: Ascorbate radical AML: Acute myeloid leukemia AE: Adverse effects BER: Base excision repair CRC: Colorectal cancer ccRCC: Clear-cell renal cell carcinoma CC: Colon cancer DHA: Dehydroascorbic acid DNMTi: DNMT inhibitors DNMT: DNA methyl transferases DLT: Dose limiting toxicity EBRT: External beam radiation therapy FIH: Factor-inhibiting HIF FH: Fumarate hydratase GLUT-1: Glucose transporter-1 -GCS: -glutamyl cysteine synthetase G6PD: Glucose-6-phosphate dehydrogenase HDVC: High dose vitamin C HDVC: High dose intravenous vitamin C HIF1: Hypoxia inducible factor-1 2-HG: 2-hydroxy glutarate IDH1/2: Isocitrate dehydrogenase iPSCs: Induced pluripotent stem cells IVC: IV vitamin C ICI: Immune checkpoint inhibitors JMDH: Jumonji-C domain-containing histone demethylases -KGDD: -keto glutarate-dependent dioxygenases LIP: Labile iron pool MDS: Myelo dysplastic syndrome MTD: Maximum tolerated dose mCRC: Metastatic colorectal cancer mGC: Metastatic gastric cancer 5mC: 5-methyl cytosine 5hmC: 5-hydroxy methyl cytosine mCRPC: Metastatic castration-resistant prostate cancer NER: Nucleotide excision repair NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NSCLC: Non-small cell lung cancer ORR: Objective response rate OS: Overall survival PSA: Prostate specific antigen PARP: Poly(ADP-ribose) polymerase PPP: Pentose phosphate pathway PFS: Progression free survival P-AscH : Pharmacological ascorbate PHD: Prolyl hydroxylase domain PCR: Pathological complete remission pMMR: Proficient mismatch repair PD-L1: Programmed death ligand-1 QoL: Quality of life ROS: Reactive oxygen species RCC: Renal cell carcinoma RCT: Randomised control trial SDH: Succinate dehydrogenase SVCT: Sodium-dependent vitamin C transporter TET: Ten-eleven translocation TME: Tumor microenvironment Tregs: Regulatory T-cells TMZ: Temozolomide TCA: Tricarboxylic acid VHL: Von Hippel-Lindau References Sharma P
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