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The prognostic impact of the reactive hyperemia index (RHI) in HFpEF patients suggests that endothelial dysfunction may not be merely a passive finding, but rather that endothelial function plays an active and crucial pathophysiological role in HFpEF [23]

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This careful progression is essential for managing tolerability

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When the skin barrier is compromised, it can lead to increased transepidermal water loss (TEWL), resulting in dryness and irritation