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doi: 10.1038/s41392-023-01570-w

Rhesus macaques were also used to study GLP-1s effects on pancreatic function and glucose metabolism, further validating the drugs mechanism and safety before human trials

B12 adequacy is associated with better cognitive aging outcomes, and the combination of neural anti-inflammatory effects from GLP-1R activation and neuroprotective effects from B12 creates a complementary pair even at doses where weight loss is not the goal

Research shows that a significant proportion of weight lost on GLP-1 medications can come from lean mass, with estimates suggesting up to 3040% of total weight loss may be muscle and bone density, rather than fat (Neeland et al

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