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Experimental evidence from knockout models suggests that reduced NNMT activity is associated with resistance to tumor formation, leading to speculation about a possible role for this enzyme in cancer biology

doi: 10.1038/s41467-023-39253-3, 16

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also found that metformin combined with oral contraceptives effectively improves hirsutism, acne, and menstrual irregularities in adolescent PCOS (Yen et al., 2021)