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Conducted experiments: Lucey, Ashik, Marzook, Wang, Goulding, Elani, Jones Contributed new reagents or analytic tools: Marzook, Oishi, Broichhagen, Hodson, Jockers Performed data analysis: Lucey, Ashik, Goulding, Elani, Jones Wrote or contributed to the writing of the manuscript: all authors Funding acknowledgements The Section of Endocrinology and Investigative Medicine is funded by grants from the Medical Research Council, Biotechnology and Biological Sciences Research Council National Institute of Health Research (NIHR) and is supported by the NIHR Biomedical Research Centre Funding Scheme

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