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Dual MAPK Pathway Modulation MAPK pathways receive dual modulation

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57 Other novel biomarkers include noncoding RNAs, 58 miRNAs, 59,60 and lncRNAs 61 (e.g., miR-21, miR-146a, miR-155, lncRNA HOTAIR, and lncRNA NEAT1)

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However, the cancer cells harbor high intracellular ROS level compared to normal cells due to high aerobic glycolysis that causes oxidative stress [3]