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Clinical trial results for the 25mg tablet are broadly comparable to those seen with the weekly 2.4mg injection, provided the tablet is taken correctly each morning on an empty stomach

and S2 Fig

However, increasing evidence indicates that macrophages in vivo do not exist as fixed binary states, but rather more closely resemble a continuum of functions jointly shaped by tissue niches, inflammatory stages, and substrate availability, with their phenotypes being collectively determined by microenvironmental signals, metabolic reprogramming, and epigenetic regulation (11, 1923)