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The antidepressant Wellbutrin has also been long-prized for its off-label ability to make cigarettes taste disgusting, a side effect that resulted in the same chemical (bupropion) being rebranded as Zyban, an FDA-approved smoking cessation aid

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Recent improvements in molecular modeling have enabled the design of new inhibitors with higher selectivity for DPP-4 than for other dipeptidyl peptidases, thus minimizing side effects [28]