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Mild water retention: A small percentage of users report temporary water retention

Protocol Quick-Reference PRECLINICAL ONLY: NNMT inhibition research compound Dosing Amount No established human dose (mouse: ~34 mg/kg/day SC) Frequency No established human frequency Duration No established human duration Administration Route Oral Schedule N/A (preclinical compound) Timing NO HUMAN DOSING DATA EXISTS

The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

This could be due to medical conditions like pernicious anemia or digestive disorders such as Crohns disease or celiac disease

Oral supplementation has shown effectiveness but may not match the efficacy of IM in certain scenarios