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Interestingly, mild to severe alterations in GSH homeostasis have been reported in multiple pathologies such as haemolytic anaemia, diabetes, liver diseases, cystic fibrosis, neurodegeneration, and cancer 18,19,20,21

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2.10 Western blot analysis Ileal mucosa samples were randomly collected from three piglets in each group ( n = 3) for protein extraction

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Specifically, the known surfaces of FBXO22 that interact with BACH1 and BAG3, another known SCF FBXO22 substrate, do not overlap with the region of FBXO22 that contains C326 and engages NSD2 in our structures with either UNC10088 or UNC10415667 13,14,24