RUNX2 Polyclonal Antibody, 20ul[BT-AP08060] Live Cell Imaging increased acidification produces increased proteolysis

increased acidification produces increased proteolysis and efficient peptide loading

each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted

They play a critical role in muscle differentiation

Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas

Involved in embryogenesis and hematopoiesis Diseases associated with HLX include ovarian endodermal sinus tumor and ovarian primitive germ cell tumor

RUNX2 Polyclonal Antibody, 20ul[BT-AP08060] Live Cell Imaging increased acidification produces increased proteolysisRUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA binding domain. Runt related transcription factor 2 is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions