Rb(Phospho Ser249) Polyclonal Antibody, 50ul Immune Repertoire Sequencing These kinases are involved in

These kinases are involved in the regulation of cell growth| differentiation and metabolism

The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein

and was first identified as being upregulated in psoriasis tissue

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling

Interacts with CUL7

Rb(Phospho Ser249) Polyclonal Antibody, 50ul Immune Repertoire Sequencing These kinases are involved inThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.