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Some observers have opined that the European agency is stricter than the US Food and Drug Administration, which has not yet addressed this issue

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These suits allege that: Merck knew Janvuia could pose a risk of pancreatic cancer and kept this information from patients and doctors The warnings on Januvia are inadequate and do not even mention pancreatic cancer Merck failed to tell doctors to monitor Januvia users for signs of changes within the pancreas Januvia poses an extreme risk and its benefits do not outweigh this risk Rather than pull the drug from the market or issue stronger warnings, Merck continues to promote Januvia as a safe and effective treatment Merck did not perform adequate safety tests Merck over-promoted Januvia and under-warned about its risks These suits are seeking a number of damages, including but not limited to lost income, diminishment of earning capacity, medical bills and pain and suffering

The column was then washed with 20 CV of DPBS/0.05% (v/v) sodium azide, followed by elution with 9 CV of 2 M MgCl 2 (Sigma-Aldrich)/20 mM Tris-HCl (Sigma-Aldrich) buffer (pH 7.4) at a flow rate of 2 mL/min