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Before prescribing GLP-1 medications to individuals with vascular health issues or previous eye complications, healthcare providers should carefully weigh the potential benefits against the risks

In consideration of the reduced compliance of peptide GLP-1 receptor agonists due to subcutaneous injection, oral micromolecular GLP-1 receptor agonists such as orforglipron have already in clinical trials, which can reduce body weight and improve cardiac metabolism in adults with obesity (Wharton et al 2023) (Fig