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Chronic impairment of lipid metabolism is closely related to oxidative stress, leading to cellular lipotoxicity, mitochondrial dysfunction, and endoplasmic reticulum stress

In the present study, we found that SLC7A11, FSP1 and GPX4, key regulators of ferroptosis, were downregulated in the aortas of Stanford type A AD (TAAD) patients, and inhibition of ferroptosis by liproxstatin-1 largely abrogated -aminopropionitrile (BAPN)-induced AD in mice

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However, reconstitution of the NAD + pool to some extent and NAD + -induced physiological effects have also been observed upon exogenous increases in eNAMPT in glioma and CRC cancer cells

For example, endocrine disruptors such as insecticides, flame retardants, and phthalates from plastics, are specifically toxic to the male hormones responsible for sperm production

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